 Conserved homeobox domain proteins are transcriptional regulators governing development in fungi, including aspergillus species, where HBXA-slash-HBX1 is involved in canidial production, germination, virulence, and secondary metabolism. Disruption of HBX1 results in fluffy aconidial colonies unable to produce sclerotia and regulates production of aflatoxins, cyclopiazonic acid, and aflatrem. Transcriptome studies revealed that HBX1 has a broad effect on the A-flavus genome, including numerous genes involved in secondary metabolism. Our study of the A-nigelin's HBXA-dependent transcriptome revealed that more than 1,000 genes are differentially expressed when this regulator was not transcribed at wild-type levels, among them numerous transcription factors, and production of several secondary metabolites was also altered in deletion and overexpression HBXA strains compared to the wild-type. This article was authored by Sundesh S. Pundit, Jean Fong Ching, Yen Benin, and others. We are article.tv, links in the description below.