 Our system has been designed to collect, store, and analyze data from neonates with and without congenital heart disease. We have successfully collected data from 190 neonates, 130 presumably without and 60 with congenital heart disease, which totals 1665 minutes of data. Using this data, we have extracted non-invasive perfusion features such as perfusion index, radiofemoral delay, and slope of systolic rice or diastolic fall. This data collection and analysis is relatively inexpensive and can be used to enhance future CCHD screening algorithms. This article was authored by Kavish Doshi, Gregory Brem, Pranjali Vadlaputi, and others.