 Burgers' disease, or thromboangitis obliterans, TAO, is a segmental non-atherosclerotic occlusive inflammatory condition of small arteries and veins of the upper and lower extremities, characterized by thrombosis and recanalization of the affected vessels. It is triggered by substantial exposure to tobacco, especially in males aged from 20 to 50. Currently, the most effective treatment, together with the suspension of the smoking habit, is represented by prostacycline infusion, iloprost. We described two cases of Burgers' disease recently presented to our observation, with some different clinical features and therapeutic pathways. This article was authored by Carlo Umberto Manzini, Gilda Sandri, and Marco Sebastiani.