 In this study, researchers derived formulas for several important neighborhood-based irregular topological indices of 2D nanotubes. These indices were then compared to gain insight into their relative importance. The results showed that the indices can be used to compare different types of 2D nanotubes and identify those with higher potential for use in various applications. This article was authored by Assad Ila, Shahid Zaman, Ashad Hussein, and others.