 A new nanofotosensitizer, YBSB MSNPs RKC, with pH response integrating immunogenic pyroptosis induction and immune checkpoint blockade is developed to stimulate a powerful anti-tumor immune response and abstract prostate cancer, suppressing primary tumor progression and evoking long-term immune memory to inhibit tumor relapse and metastasis. This article was authored by Yuan, Zhang Xinyi, Yijian Gao, and others.