 To start a new project, click the Start Modeling button. There are four different types of input that can be provided to Swiss model. The most frequently used input is either the protein sequence or the access codes for the protein from Uniprot. However, many different input formats are supported and you can either copy-paste the sequence or upload a file. Just make sure it is a plain text file, no doc, PDF and no screenshots. If you want your own alignment to a given template, you can choose the Target Template Alignment option. If you want to upload a structure as a template, you can choose the User Template option and upload a structure there. Finally, if you are a user from the program DeepView, you can choose the DeepView project option. Here we will use the Uniprot KB access code which is P61851. As you can see, this has also the advantage that a proper project title is set automatically. The first step in homology modeling is the identification of good templates. This is done by pressing the Search for Templates button. It uses both Blast and HH Blitz to find suitable templates. If you are not logged in, I suggest you bookmark this page. The template search itself usually takes less than 15 minutes.