 The study develops a multi-objective optimization method using response surface methodology, RSM, and non-dominated sorting genetic algorithm to NSGAII for lightweight structures in the aerospace and military fields. Selective laser melting, SLM, is used to design and fabricate multi-layer bio-inspired sandwich structures of T6L4V alloy. The study shows that RSM and NSGAII can optimize the structures with a relative error rate less than 10%. The results indicate that increasing the layer number of cores improves comprehensive mechanical performances in cross-arranged configurations, but decreases energy absorption capacity in parallel arranged configurations. The two-layered bio-inspired sandwich structure under cross-arranged configurations has the best comprehensive performance, with specific energy absorption of 9.16 x 103 j o kg, and energy absorption of 154.80 j. This article was offered by Liang Meng, Jianjiao, Qin Xianglan, and others. We are article.tv, links in the description below.