 Cancer metastasis is the primary cause of cancer morbidity and mortality, accounting for about 90% of cancer deaths. Despite improvements in cancer survival rates due to early diagnosis and growth inhibition, limited progress has been made in treating cancer metastasis through chemotherapy, radiotherapy, and new generation anti-cancer drugs. The metastatic process involves detachment, migration, invasion, and adhesion of cells, which are interrelated and influenced by multi-biochemical events and tumor microenvironment factors. These biochemical events and parameters can be targeted for metastasis prevention and inhibition. This article was offered by Sha Mingguan.