 The study investigates whether there is an association between clinical phenotype and molecular structures of amyloid fibrils in ATTRV amyloidosis patients carrying the I84S mutation using cryoelectron microscopy to determine the structures of cardiac fibrils extracted from three patients, finding that each patient exhibited different local confirmations within the same fibril, suggesting that one amyloid disease may associate with multiple fibril structures in systemic amyloidosis. This article was offered by Binan Nguyen, Varender Singh, Chumaila Afrin, and others.