 Aging is the main risk factor for chronic age-related diseases and geriatric syndromes, and they share a common set of basic biological mechanisms. As a result, the primary target of medicine should be combating aging instead of treating each disease individually. This new interdisciplinary field, called geroscience, focuses on understanding the relationship between aging and chronic age-related diseases and geriatric syndromes. It is hypothesized that aging and chronic age-related diseases and geriatric syndromes are part of a continuum, with precise boundaries not existing and the two extremes being represented by centenarians who largely avoided, or postponed most chronic age-related diseases and conditions, and patients who suffered one or more severe chronic age-related diseases and conditions in their 60s, 70s, and 80s and showed signs of accelerated aging. In between these two extremes, there is a continuum of intermediate trajectories representing a sort of grey area. Clinical differences between classical chronic age-related diseases and conditions and accelerated aging are due to unique combinations of alter. This article was authored by Claudio Franceschi, Paolo Garignani, Paolo Garignani, and others. We are article.tv, links in the description below.