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Published on May 7, 2014
Infliximab is a chimeric monoclonal antibody that targets tumor necrosis factor-alpha and is used to treat a variety of chronic autoimmune disorders such as rheumatoid arthritis, Crohn's disease and ulcerative colitis. Monitoring serum infliximab concentrations is important in guiding disease management, especially when a patient is not responding well to treatment. Infliximab concentrations can determine if loss of efficacy is due to inadequate dose or to the development of anti-infliximab antibodies.
Currently, 3 reference labs offer quantitative infliximab testing. However, the high cost of these tests limits frequency of use. Here, using the ProteOn XPR36, we describe development of a quantitative assay for infliximab in serum, and explore the practicality of using surface plasmon resonance in the clinical lab.