 This research aimed to explore the potential of mushroom residues, MR, to create a sustainable and cost-effective method of making vermicompost that could resist fusarium oxysporium, FO, in maize crops. The study found that the best results were obtained when MR was combined with aqueous extracts of licorice residue, LR. This combination resulted in a decrease in the incidence of wilt disease caused by FO, with a disease severity score of 1.90. Additionally, the roots of treated maize plants showed higher levels of peroxidase and polyphenoloxidase activity than those of untreated plants. This article was authored by L. Seit A. E. R. Lee, Mariam A. Amair, Abdelgawad Saad, and others.