 Sustainable livestock production can refer to practices that aim to meet the needs of resting animals for food while minimizing negative environmental impact. Sustainable livestock production promotes the long-term availabilities of agri-food system, protects natural resources, improves economic lesions, and contributes to the more sustainable and lesilient future. To produce more with less impact, we must first focus on improving the efficiencies of livestock system. This includes optimizing feed conversion, reduce feedwares, enhancing nutrients utilization, reducing the degradation of land and water resources, decreasing greenhouse gas emissions, and mitigating environmental degradation. In addition, we must prioritize the adoption of climate smart agriculture and livestock practices. FAO provides technical assistance to the countries in developing and implementing policies and strategies for sustainable livestock production, including climate smart practices. FAO conduct training, programs, and workshop to enhance the capacities of farmers, extension workers, and policymakers in adopting climate-friendly livestock production techniques. FAO supports research and innovation in livestock production system, including the development and dissemination of climate smart techniques and practices. Human and animal health are closely linked in several ways. For example, zoonotic disease can be transmitted between animal and humans during the past decades. We have seen the outbreak of COVID-19, Ebola, and avian influenza. Transmission can occur to direct contact, consumption of contaminated food or water, or vectors like mosquitoes and take. Controlling zoonotic diseases requires understanding and addressing their origins in animal population. The misuse and overuse of antibiotics in animal production can contribute to the development of entry microbial resistant AMR, which can then affect human health and animal health, leading to global economic losses. Ensuring the health and welfare of animals in the food production chain is essential for safeguarding food safety. Animal soft foods play critical role in a healthy diet, provide essential nutrients that are important for human health. However, it is important to note that a healthy diet can be achieved through a variety of food sources, including plant-based options. Balancing the consumption of animal and plant-based foods can contribute to a well-being and nutrient-dense diet. Small-scale producers often have limited access to land, water, and other natural resources, often struggling to access finance and credit to invest in their livestock operations. Many small-scale livestock producers lack access to training, extension services, and technical support. Small-scale livestock producers are often more vulnerable to the impacts of climate change and natural disasters. Supporting small-scale livestock producers is crucial for enhancing rural livelihoods, food security, and sustainable development. Addressing these challenges require comprehensive interventions, including improving access to resources, providing financials and technical support, strengthening market linkages, promoting climate resilience, and enhancing animal health services. At this Global Conference on Sustainable Livestock Transformation, we address a pressing challenge how to produce more with less environmental impact in the livestock sectors. The Global Conference can provide an opportunity to highlight the findings and key messages contributing to the global dialogues on sustainable livestock production, and it grows in climate change, mitigation, and adaptation. Overall, the conference plays a crucial role in advancing the agenda of sustainable livestock productions and promoting holistic approaches that address environmental, social, and economic aspects for livestock systems.