 This research paper investigates the role of EFTUD2 in the regulation of interferon, IFN, mediated antiviral responses against hepatitis B virus, HBV. It was found that EFTUD2 is a novel innate immune regulator of the IFN anti-HBV response. EFTUD2 was shown to reduce the expression of ISG-encoded proteins, such as MX1, OAS1, and PKR, EIF2-AK2, through mediated gene splicing. This suggests that EFTUD2 may play a role in modulating the expression of these genes, which are important for IFN-mediated antiviral responses. Additionally, EFTUD2 was also found to be involved in the regulation of IFN receptor and signal transduction components, suggesting that it may act as a non-canonical IFN effector. Overall, this study provides new insights into the molecular mechanisms of EFTUD2's involvement in IFN-mediated antiviral responses. This article was authored by Ping Ping Hu, Yuan Li, Wen Zhong, and others.