 The nucleus of differentiating cells undergoes a process of self-organization, with its constituents forming a complex network of interconnected elements. This network is further characterized by distinctive patterns of gene expression and chromosome topology, which together form a unique cell-specific signature. Additionally, the individual elements themselves consist of multiple intacting components, which can be represented through the use of networks. By studying these networks, researchers have been able to identify how they rewire according to certain rules, resulting in a higher level of order and complexity. This article was authored by Indika Rajapaks, David Scalzo, Steven J. Tapscott, and others.