 This article explores the effects of salt additives on the dilation of hydroxypropyl methylcellulose, HPMC, and its role in bio-related applications, including oral drug delivery systems. The thermoreversible behavior of HPMC is affected by various factors such as concentration in solvent media, nature of additives, and thermal environment. The study examines the swelling, dissolution, and dispersion of HPMC tablets in simulated biofluids and the release of a drug from the tablet. The obtained test data and established mathematical models are expected to guide customizing applications of HPMC hydrogels. This article was authored by Sunil C. Joshi.