 Qytosan has been identified as a promising material for use in wound dressing applications due to its bioadhesive properties. Our study compared the bioadhesive properties of Qytosan with those of carbapol, a synthetic polymer. We found that Qytosan-based hydrogels had similar cohesiveness and adhesiveness to carbapol-based hydrogels, but Qytosan-based hydrogels retained more formulation on the skin after testing. This suggests that Qytosan may have greater potential for use in advanced wound therapies.