 Glioblastoma multiforme, GBM, the most common and lethal tumor of the adult brain, is typically resistant to chemotherapy and radiation. MicroRNAs, mirrors, regulate physiological processes, such as resistance of GBM cells to Tamazolamide, TMZ. Although mirrors are attractive targets for cancer therapeutics, the effectiveness of this approach requires targeted delivery. Mesenchymal stem cells, MSCs, can migrate to the sites of cancers, including GBM. We found that MIR9 is expressed at higher levels in TMZ-resistant GBM cells. MIR9 is involved in the expression of the drug efflux transporter, P-glycoprotein. To block MIR9, we developed methods using SI5 tagged anti-MIR9. These methods demonstrated intracellular communication between GBM cells and MSCs via gap-junctional intracellular communication and the release of micro vesicles. Anti-MIR9 was then transferred from MSCs to GBM cells, which reversed the expression of the multidrug trans. This article was authored by Jesse and Almonios, Sarah A. Bliss, Stephen J. Greco, and others. We are article.tv, links in the description below.