 This study examined the effects of severe COVID-19 on the immune system and found that patients experienced a reversal of immune activation at the six-month follow-up period. However, the study also noted that there was still evidence of exhaustion in the immune system, suggesting that further research should be conducted to understand how these changes affect long-term recovery from the virus. This article was authored by Elena Vasquez Alejo, Laura Tarencández, Maria de la Sierra Espanobutrago, and others.