 You know the feeling you get when you learn something new about a health problem you've been trying to reverse? Maybe high blood pressure, diabetes, or heart disease? Well, there's nothing I like better than bringing you the information that will help you do just that. Welcome to the Nutrition Facts Podcast, I'm your host, Dr. Michael Greger. Today we begin a fascinating new series on treating Parkinson's with diet. And we begin with a question. Since Parkinson's is caused by a dopamine deficiency in the brain, what if you ate foods rich in the dopamine precursor and leave adobo? Two centuries have passed since James Parkinson's essay on the Shaking Palsy described a disease characterized by tremor and problems with movement. Today treatment options include surgically implanting electrodes into the brain. There has to be a better way. Who knows since the 1950s that Parkinson's disease is manifested by a dopamine deficiency in the brain? Well, then why not eat a dopamine diet? A variety of fruits and vegetables contain the same dopamine made by our brain. Unfortunately, dopamine can't cross the blood-brain barrier and hence is ineffective as therapy. However, the dopamine precursor, known as L-dopa or Liva-dopa, can get from the blood up into the brain, where it can then be converted to dopamine within the brain by an enzyme called decarboxylase. We don't want the Liva-dopa to be converted to dopamine outside the brain because then it can't get in, so we give people a decarboxylase inhibitor which itself can't get into the brain, so that keeps Liva-dopa from prematurely turning into dopamine before it gets into the brain where we need it. So eating dopamine-rich foods doesn't help, but what if we ate Liva-dopa-rich foods? More than 1,500 years before Dr. Parkinson came on the scene, an Indian physician seemed to have nailed it and even suggested a treatment, though that means the plant with the highest amount of L-dopa. So might there be a way to forestall the epidemic of Parkinson's disease through plant-based remedies after all? Liva-dopa is the gold standard therapy for Parkinson's patients, but most Parkinson's patients in low-income areas cannot afford long-term daily Liva-dopa therapy. In rural Africa, for example, it's estimated that only 15% of patients are treated with Liva-dopa because the daily cost of Liva-dopa treatment is about a dollar a day, which may be half of what people make in a day. Same with other regions in the global south. L-dopa is mostly unavailable or unaffordable, so patients frequently use powdered velvet beans as a replacement or supplement to the drug. But does it work? You never know until you put it to the test. Velvet beans in Parkinson's disease are randomized, double-blind clinical study, and a dose of 30 grams, which is about three tablespoons, led to a reliable and sustained anti-Parkinsonian effect in all patients working significantly quicker than the drug, working significantly longer than the drug, and working significantly better than the drug, and another double-blind randomized head-to-head crossover study. The Liva-dopa in velvet beans appears to be two to three times more potent as compared to the same dose of pill-formed Liva-dopa, suspected to be because there may be some intrinsic decarboxylase inhibitor compound in the plant as well. Okay, but those were single-dose studies. What about the chronic use of velvet beans for Parkinson's? 14 patients with advanced Parkinson's received roasted velvet bean powder or the standard drug, switching back and forth for months, looking at changes in quality of life, activities of daily living, movement, and non-moving symptoms, and time with good mobility without troublesome involuntary writhing movements, and the velvet beans seem to work as well as the drug in all measures of efficacy, including quality of life, despite the efficacy. The chances of this cheap herbal remedy ever being licensed seems unlikely, and for good reason. First of all, the stuff evidently tastes nasty, and we don't really have good data going out more than a few months, while velvet beans may potentially be part of the answer to Parkinson's disease management in low-income countries and high-income countries. One may be tempted to prefer them to drugs, just because it's a more natural therapy, but researchers discourage patients or physicians to consider its use when the drugs are available, so leave it open. Pill form should remain the first-line treatment for Parkinson's. However, velvet bean powder may be better tolerated in certain patients. Psychologically, some patients just have a thing against taking pills, and so if they refuse, then certainly the beans can step in. But otherwise, velvet bean supplements suffer from the same issues common to all supplements, specifically lack of sufficient regulation and quality control. There's all sorts of brands out there, but there's no head-to-head comparisons as to which is best, and the quality of the products likely vary, but you don't know until you put it to the test. Six brands of velvet bean product were ordered through the internet, and most of them, four out of six, showed a large discrepancy between the claim on their label and the actual Eldopa content, and only two even came close. The remaining products contained considerably less, less than 10% in two cases. Too bad there isn't a food source of Eldopa that you could just eat instead of taking in a supplement. Wait a second, Eldopa was originally discovered more than a century ago in fava beans. Might eating fava beans help with Parkinson's? I'll explore just that question next. Increased risk of Parkinson's disease has been associated with exposure to pesticide, consumption of dairy products, a history of melanoma, and traumatic brain injury. Why is the risk of Parkinson's disease increased among individuals with high milk and dairy consumption? Could be the animal fat, maybe the animal protein. So why not use a plant food diet for the risk and management of Parkinson's disease? There are phytochemicals that may target the underlying cause, but in terms of treatment, ancient sacred texts from thousands of years ago refer to trembling individuals who were prescribed a plant from the bean family to treat the condition. But in 1913, the miracle drug Eldopa was discovered for the first time in fava beans, also known as fava beans or broad beans, as a natural source of Eldopa to consider. The amount varies considerably based on a number of factors, but typically it looks like they have about 10 times less than velvet beans, but that's okay since you can eat larger quantity since fava beans are an actual food instead of a powdered supplement. The important thing is that the amount of Eldopa in fava beans is enough to be pharmacologically active in Parkinson's disease. In fact, there are some reports indicating that Parkinson's patients might respond better to the beans than to standard Eldopa preparations in pill form. But anecdotal reports that patients may gain benefit from a broad bean-rich diet don't cut it. What you have to do is put it to the test. Parkinson's patients were fed about one-third cups of cooked fava beans, and during the next four hours, a substantial clinical improvement was noted. In fact, similar to the improvement seen after receiving the standard pharmacological combination of Eldopa plus facarbodopa, the decarboxylase inhibitor drug I talked about in the last video that boosts Eldopa levels in the brain. No surprise that there was a similar effect since they had very similar Eldopa levels in the blood. In fact, half the time, you could hardly tell the beans from the drugs. How could there be the same levels if the bean Eldopa lacked the carbidopa booster drug? Because fava beans may not only be a natural source of Eldopa, but a natural source of the carbidopa booster too. So, the consumption of fava beans has the potential to increase the levels of Eldopa and carbidopa in the blood with a market improvement in muscle movement performance of the patients with Parkinson's disease without any side effects. In fact, they work so well, you have to be careful about abruptly stopping them. There's a condition called neuroleptic malignant-like syndrome, characterized by fever, rigidity, all sorts of neurological problems, muscle breakdown, altered levels of consciousness, which is usually precipitated by an abrupt withdrawal of the Eldopa drug, caused by an acute dopamine-deficient state. Well, you can see the same thing if you're treating your Parkinson's with fava beans and then all of a sudden stop them. Alternative therapies carry similar risks to traditional agents, because in this case, they really are the ultimate traditional agent. There are some downsides you don't see with the drug though, like fava-induced flatulence. You also have to be careful with fava consumption if you're on MAO inhibitor drugs, often use this antidepressants since there can be drug interactions. And then there's the risk of a condition known as favism. There's a genetic mutation that occurs in about 120 people and that even higher rates in those of African, Asian, and Mediterranean percent, in which people lack an enzyme that's necessary to detoxify certain compounds found in fava beans. And without the enzyme, fava bean consumption can cause your red blood cells to rupture. Thankfully, genetic testing for this mutation is widely available and affordable, so it seemed prudent to screen patients with Parkinson's for this fava-ism, what's called G6PD deficiency, mutation prior to putting them on daily fava bean consumption. If you want to give fava beans a try, fresh green fava beans have significantly more el dopa than dried, so much so that dried fava beans may not provide any clinical benefits. Roasting and boiling remove some or even all of the el dopa, though other studies have found about a half cup of cooked fava contained approximately 250 mg. Sprouted favas may have the most increasing up until day 9, by which time the indigestible flatulence sugars may be eliminated, offering another advantage of fava bean sprouting. But you don't know if fava bean sprouts help until you put them to the test. Researchers fed Parkinson's patients a salad with about a half cup of freshly chopped fava sprouts and observed substantial clinical improvement. Other beans, just like regular beans, also naturally have el dopa, though at lower amounts, soybeans have a bonus compound that may act as an el dopa boosting carbidopa compound. What if you fed people soybeans on top of their regular Parkinson's meds? Giving people just one half spoonfuls worth of roasted soybeans led to a significant improvement over the drugs alone with significantly fewer involuntary movements hours later. Until more information is available, Parkinson's combo drugs like cinnamon should remain the first line therapy, but adding beans to one's diet may only help. We would love it if you could share with us your stories about reinventing your health through evidence-based nutrition, goodnutritionfacts.org slash testimonials, we may share it on social media and help inspire others. Scenic graphs, charts, graphics, images, or studies mentioned here, please go to the Nutrition Facts Podcast landing page. There you'll find all the detailed information you need, plus links to all the sources we cite for each of these topics. My last two books are How to Survive a Pandemic and the How Not to Diet book. Stay tuned for December 5, 2023, for the launch of my new one, How Not to Age. And of course, all the proceeds I receive from the sales of all my books goes directly to charity. 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