 This study reports the use of iridium single-atom IRSA-NC as a robust hydrogen evolution reaction, HER, and hygrosine oxidation reaction, HERTSOR, electrocatalyst in 0.5 mH2SO4 electrolyte, achieving high mass activity and superior stability compared to PD-C in point-slash-C. The study also shows that the hygrosine-assisted water splitting process requires only 0.39 V versus RHE to drive, which is 1.25 V lower than acidic water splitting. This article was authored by Fong Luo, Xu Yuan Pan, Yu Huo Xia, and others.