 This study investigated the effects of sodium thiosulfate, STS, a precursor of hydrogen sulfide, H2S, and an antioxidant on maternal chronic kidney disease, CKD, induced hypertension in offspring. It found STS can reduce hypertension in offspring born to mothers with CKD, which may be due to its ability to increase levels of H2S and nitric oxide, NO. Additionally, it was observed that STS can improve gut microbiome composition, which may further explain its protective effect against hypertension. This article was authored by Yulin Tain, Qiaohou, Guoping Changqian, and others.