 Hepatitis C virus, HCV, can cause chronic liver disease, but it can also lead to extreopatic manifestations such as mixed cryoblobulemia, lymphoproliferative disorders, and renal disease. In addition, HCV has been associated with distinct histological patterns of glomerulonephritis and native kidneys. This article was authored by Liano Rosting, Jacques Isopet, and Nazim Kumar.