 The present study demonstrated that the combination of Plumbago xalanica and Smilax corbularia and Smilax glabra extracts, PSS, can effectively reduce the proliferation of breast cancer cells. Furthermore, this combination also induced apoptosis in these cells by downregulating the expression of genes involved in the relevant pathways. These findings suggest that PSS could potentially be used as an alternative therapy for breast cancer patients. This article was authored by Kamala Chalapet, Thana Wich Sankiripud, Prakithip Somjit and others.