 The abstracted article discusses a new method for studying the effects of external injuries on the blood-brain barrier. This method uses a human cell-based platform with integrated transparent electrodes to measure barrier tightness in real time. The platform consists of human cerebral endothelial cells and primary parasites and astrocytes arranged in a three-dimensional structure. When exposed to an oxygen-glucose deprivation event, the cells undergo morphological changes and form large actin-stress fiber bundles. These bundles cause the barrier to become less resistant and eventually break down. The authors conclude that this platform can accurately replicate the behavior of the blood-brain barrier when subjected to external injuries and can therefore be used to study the effects of these injuries on the brain. This article was authored by Wei Wei, Fernando Cardez, Andreas Heelman and others.