 Takatsubo cardiomyopathy is a type of stress-induced cardiovascular disease characterized by symptoms similar to those of an acute coronary syndrome but without any evidence of coronary obstruction. It has been thought to be spontaneously reversible, but recent research suggests otherwise. In this study, researchers have shown that a single pharmacological challenge can create a stress-induced cardiomyopathy in female rodents, which is similar to takatsubo. This acute response is accompanied by changes in blood and tissue biomarkers, as well as in cardiac in vivo imaging acquired with ultrasound, magnetic resonance and positron emission tomography. Long-term follow-up reveals continued metabolic reprogramming of the heart towards metabolic malfunction, ultimately resulting in irreversible damage in cardiac function and structure. These findings suggest that takatsubo is not reversible and instead points to dysregulation of glucose metabolism as a primary cause of long-term cardiac disease. Furthermore, they support early therapeutic management of Takatsubo.