 Copper is an essential micronutrient that plays a critical role in many biological processes. It is also a pro-oxidant and can cause damage if not properly controlled. Recently, researchers have discovered a new type of cell death called cuproptosis, which is caused by copper binding to lipolylated enzymes in the TCA cycle. This causes protein aggregation, proteotoxicity, and eventually cell death. Cuproptosis has been linked to several diseases such as Wilson's disease, neurodegenerative disorders, and cancer. Targeting cuproptosis may be beneficial in treating these diseases. This article was authored by Liun Chen, Duan Xiaominit, and Fudi Wang.