 The study proposes a strategy to develop hollow-structured rough nanoplatforms that boost anti-tumor immunity and reverse immunosuppression by encapsulating CO-prodrug within MnO2 nanoparticles, surface functionalization with HA, and TME responsive degradation. The IMH nanoparticles induced intrinsic cell maturation and M1 macrophage polarization through sting pathway activation and hypoxia alleviation, leading to enhanced anti-tumor immune responses. After combination with APD-L1 mediated checkpoint blockade therapy, robust anti-tumor immune responses are found to inhibit both primary and distant tumours. This article was authored by Beibei Chen, Kangli Guo, Xiaoyou Ijiao and others.