 Non-coating ironase have been implicated in the development of colorectal cancer, CRC. These ironase can alter gene expression and regulate cellular processes such as DNA repair, chromatin remodelling, and cell cycle control. They can also affect the activity of other genes, leading to changes in cell growth and differentiation. Furthermore, they can interact with other proteins to form complexes that modulate cellular functions. Non-coating ironase have been found to be over-expressed in CRC cells compared to normal cells, suggesting that these ironase could be important regulators of CRC development. This article was authored by Yijijiu, Hijojiao, Luzeng and others.