 Thermosensitive gels composed of copolymers such as PEG kytosan, kytosan polyethyleneamine, kytosan arginine and glycol kytosan spermine have been developed as promising polycations for the formation of DNA polyplexes and the potential for the development of drugs with prolonged release up to 30 days. These compounds are in liquid form at room temperature and can be injected into muscle tissue with rapid gel formation upon exposure to human body temperature. This results in the formation of an intramuscular depot containing a therapeutic agent that provides a gradual release of the drug such as an antibacterial or cytostatic. The physical chemical parameters of the formation of polyplexes between these polymeric materials and DNA were studied using FTIR, UVVIS, and fluorescence spectroscopies. The competitive displacement of dye molecules from DNA polyplex complexes indicated that when a ratio of n slash p equals 1, most of the DNA is bound to a polycation. Furthermore, the electroph. This article was authored by Igor D. Slotnikov, Stanislav M. Malyshkevich, Natalia G. Belogirova, and others. We are article.tv, links in the description below.