 The stoke is the third leading cause of death in the world. And the first leading cause of death in China, 6.5 million stoke days occurred annually in the world. Last stoke is a major health problem and caused huge economic burdens in the world. Although age standardized the mortality of stoke and the fatality of stoke reduced, however, the absolute number of stoke days and the crude mortality rate were still increased in the past 10 years, especially in the rural. Stoke risk can affect anyone, from common people, physicians, to celebrities, like a former president of the United States, Roosevelt, and a former prime minister of the United Kingdom, Sacho. In just the last minutes, 13 stoke days occurred in the world. Within this comfort zone, about more than 20 individuals here, it's estimated around two to three individuals will be died of stoke in our lifetime. How could we identify those at high risk for stoke and prevent a stoke epidemic? In the United States, age standardized mortality were reduced 40% in the past 10 years. The major improvement of stoke outcomes were from primary and second prevention, suppose you had close relatives who had stoke at his younger age and you are more likely to develop stoke, but you cannot change your genetic background and reverse your age. Something we still can do for prevention of stoke. There are several major modifiable risk factors for stoke, including hypertension, dyslipidemia, diabetics, and actual vibrations. Hypertension can significantly increase the risk of stoke if it's not well under control. In addition, lifestyle, like smoking, unbalanced dietary behavior, physical inactivity, and too much work stress, or increase the risk of stoke. Identifications, high risk of individual for stoke is not totally relied on single risk factors. For example, a hypertensive man aged 45 years and a diabetic woman aged 55 years, who is at a high level of risk? That's a multi-variable prediction model is needed to solve this problem. Academy societies produced cardiovascular risk prediction model, America's Stoke Association's developed stoke risk scorecard, and similar workers we are working on in China. Well, let me ask you a question. Have you ever used the stoke prediction model before? In fact, there are not quite used often in clinical setting. Later on in your life, this model can predict the risk of stoke well at population level, but not precisely at the individual level. How can we do dealing with these problems? In the last 15 years, genomic studies identified some genetic markers associated with stoke. And last year, the United States launched the Precision Medicine Program, in which the major focus is to figure out genetic signatures with stoke, and provide the opportunity to predict the risk of stoke at the individual. In clinical setting, modern technologies, such as CT angiographic, MMR, and pathocity, all can provide precise molecular phenotypers for subclinical and clinical stoker patients. Now in the era of big data, hospital informations, labors informations, and electronic medical records and packets are essential for integration information from general populations, auto-clinical, and stoker patients, in terms of prediction model development and the prevention of stoke. In conclusion, stoke is a complex disease and the main health problem in human beings. Multi-variable prediction model integrating genetic signature with molecular phenotyping image could be an advanced and precise tool to prediction of a stoke at the individual, and could be used in prediction, prevention, and management in coming years for stoke. So thank you for your attention.