 This review aims to provide an overview of silver nanoparticles, AGNPS, and their properties that contribute to their use as biocides and environmental cleaners. The study shows that the physiochemical properties of AGNPS, such as size, shape, concentration, agglomeration, and aggregation interaction with a biological system, can cause impairment of mitochondrial function prior to their penetration and accumulation in the mitochondrial membrane. The review highlights the importance of understanding the toxicity mechanisms of AGNPS, and their applicability in various sectors. This article was authored by Mammouda actor, M.D. to Juddens siktor, M.D. Mostaphyzer-Roman, and others.