 Everything we know today and we use in the clinic to fight cancer and to cure cancer patients or prolong their life and increase their quality of life relies on years of basic research. My name is Andres Sottoriva, I'm a professor of cancer genomics and evolution and I'm the head of the Center for Computational Biology at Human Technology and I also lead a lab that works on tumor evolution and cancer genomics. In the research center for computational biology at Human Technology we study cancers from different perspectives. In my laboratory we try to understand how tumors change over time and evolve to become first aggressive and metastatic and then resistant to treatment. What's very exciting about my research is that a fundamental conceptual framework that we use to understand how tumors change over time and become resistant to treatment is evolutionary biology. So we investigate the fundamental laws of evolution that drive change in cells with the aim of designing new therapies but also combine existing therapies in a way that will prevent these emergence of resistance and basically prevent losing control of the disease of a cancer. It's a bit like a chess game, so we can't win with one single move. There is no predetermined strategy. You play with the adversary, in this case you play against the cancer a sort of chess game of strategy where you make strategic moves that down the line allow you to win the game in the long run and that's what we aim at developing in the context of oncology. We use basic research from evolutionary biology combined with computational methods to play cleverly the strategy against cancer with existing drugs that we have and also novel drugs that we have. Basic research nowadays has become a very interdisciplinary effort. It requires the collaboration and interaction of a wide variety of scientists from different disciplines, from mathematics to clinical oncology or clinical research to biology and molecular and biochemistry. It's a challenge that we take and we are tackling head-on in a human technical by combining expertise of different and different backgrounds of different scientists in the same institute. So we have different centres with very different research programmes that collaborate together and we tackle this new challenge of interdisciplinary research by putting people in the same place and make people talk to each other and develop radically new ideas that they would not be able to develop if they were in isolation.