 the Italian Society of Hygiene, Preventive Medicine and Public Health, Citi, the Italian Society of Pediatrics, SIP, the Italian Federation of General Practitioners, FIMP, and the Italian Federation of General Medicine FIMMG have successfully collaborated since 2012 to produce evidence-based recommendations on vaccination schedules in Italy. The lifetime immunization schedule was developed based on their work, which introduced a life-course approach to vaccination and served as the basis for the 2017-2019 Italian National Prevention Plan. This report presents the structure, content, and supporting evidence of the new 2016 lifetime immunization schedule and highlights the influential role of medical scientific societies in researching and advocating for effective and safe vaccination programs implementation at the national level. This article was authored by Paolo Bononi, Giampietro Chiamenti, Giorgio Comforti, and others.