 This study investigated the relationship between CD147 expression and clinical features in patients with systemic lupus erythematosus, SLE. It found that CD147 expression was significantly associated with serum creatinine levels in patients with class 3 and 4 lupus nephritis. This suggests that inflammation at the glomerulus may be linked to poorer outcomes in these patients. This article was offered by Masuda Miri, Farima Abedini, and Azhar Beridharan.