 Adaptive Optics, AO, is a technology used in ophthalmology to improve the resolution of retinal images. It does so by reducing the effects of optical aberrations caused by the eye's natural lens, allowing for clearer and sharper visualization of retinal structures. AO can also be used to analyze temporal dynamics of retinal features, as well as to register multiple images taken from different angles. However, AO can be challenging to implement on large areas of the retina, requiring complex algorithms to accurately align images. To address this issue, we developed a non-rigid registration algorithm that uses local deformation corrections to compensate for distortions in the image. This allows for accurate alignment of large retinal regions, resulting in improved definition of retinal microstructures and enhanced diagnostic capabilities. This article was authored by Mircha Mujat, James Diakula, NB Fulton, and others. We are article.tv. Links in the description below.