 So to recap, what I need to find a way is in an energy landscape I need the barriers to be reasonably low and the way a barrier is low is if I have to search a bit but I don't have to search a lot to get over it. Why do we talk about searching? Well remember those curves I showed you right? When I'm moving from the unfolded to the folded states the energy helps me but I'm working against the entropy so it's an entropy barrier and entropy barriers are always about searching. Unfolding is much easier. Unfolding then I just have to heat it so it's easier to get over energy barriers when I unfold it's very hard to get over entropy barriers when I fold because I have to search. So I just need to find some sort of hierarchy if I first do A and then do B and then do C. I don't have to search as much.