 The PI3K-AKT-MTOR signaling pathway is a complex network of proteins involved in various cellular processes, including cell growth, differentiation, and survival. It has been implicated in several diseases, including ischemic brain injury, neurodegenerative disorders, and cancer. Several drugs targeting this pathway have shown promise in preclinical studies, and some have been tested in clinical trials for treating hematologic malignancies and solid tumours. This article was authored by Fei Xu, Lixin Na, Yin Fei Li, and others.