 Plants are a valuable source of new drugs with medicinal importance in drug development and secondary metabolites derived from plants have various applications such as drugs, flavor and fragrances, dye and pigments, pesticides and food additives. The evolving commercial importance of these metabolites has led to an interest in altering their production through tissue culture technology which can be established routinely from ex-plants and bioreactors are used for commercial production. This review focuses on the Phitho-therapeutic applications and recent advancements in the production of important plant pharmaceuticals. This article was authored by M.D.Sarfaraj Hussain, Shiba Fareed, Saba Ansari and others.