 This study found that saccubitrile valsaltin, SAC-VAL, can improve cardiac function and reduce fibrosis in a rat model of chronic mitral regurgitation, MR. It also showed that SAC-VAL can improve mitochondrial quality by reducing oxidative stress and depolarization, as well as upregulating autophagy-related, mitophagy-related, and natriuretic peptid system genes. These results suggest that SAC-VAL may be an effective treatment for MR. This article was authored by Lalida Tantissuot, Nakawi Senklob, Pakit Boonpala, and others.