 Viral infections play an important role in human diseases and recent outbreaks in the advent of globalization and ease of travel have underscored their prevention as a critical issue in safeguarding public health. Despite the progress made in immunization and drug development, many viruses lack preventive vaccines and efficient antiviral therapies, which are often beset by the generation of viral escape mutants. Thus, identifying novel antiviral drugs is of critical importance and natural products are an excellent source for such discoveries. In this mini-review, we summarized the antiviral effects reported for several natural products and herbal medicines. This article was authored by Liang Zenglin, Wang Chansu, and Chen Qinglin.