 A cross-sectional survey was conducted in Odisha, India, to assess the concerns of safety and acceptance for the COVID-19 vaccine among the community. The results showed that while there is a strong agreement on the safety of the vaccine for adults and children, there are significant variations in opinions regarding other aspects such as effectiveness in infection prevention, safety in children, mandatory vaccination by government, and public health protection following government guidelines. The major barrier to COVID-19 vaccination was found to be safety and awareness, but there is a well-acceptance of the vaccine among the community in Odisha, India, and further efforts to create awareness concerning safety and vaccination will be instrumental in eradicating this infection. This article was authored by Dibya Sunderpanda, Ranjan Kumar Giri, Anil Kumar Nagarajappa and others.