 There are a few examples that don't fall in this classes even of globular proteins Disordered proteins. Do you see all the green parts here? I've actually shown you an example like that before. Do you remember when I showed you that toxin? This too is a spider toxin from a Tarantula. I think We do not I don't know exactly about this molecule But the reason why things are disordered is you should think again when and how are they disordered? And in this particular case it was disordered when I determined the structure of it. That's obvious. Well Think once more Why would something be disordered in a structure? It might have more than one structure. What if this protein were to bind to another protein? Compare that to the prions. So in particular for toxins It's quite common that they might appear a bit disordered in their isolated shape And somehow they would interact with other proteins in the cell and maybe Maybe get more structure and then in general that's something that happens for Disordered proteins that they're just disordered in one of their forms But when they're interacting with and binding other proteins they might actually create more secondary structure here and of course if we now determine the structure of the protein in Isolated form without those interaction partners. Of course, it's gonna be disordered. So disordered Normally if you had to take a bet if I were to show you this and say that is this just a bad structure Or is it likely that there really were some beta strands here? To tell the truth if I if this was a protein that I knew absolutely nothing about I would probably say that it might have been a bad structure It's more likely that we have a regular structure, but more likely it does not mean never There are certainly lots of very interesting proteins that are disordered and we're learning more of them every year now It's a fairly hot area and this is an area when NMR spectroscopy is awesome because NMR spectroscopy can tell you how these disordered behave in actual water solution at 300 Kelvin and also what residues are interacting with what? That we can't get from Crye or X-ray crystallography