 Hi, I'm Dr. Ace Kalma from Concord Hospital and I'm extremely honored to be one of the recipients of the 2023 Brain Foundation Research Grant. Spinal muscular atrophy and motor neuron disease are neurodegenerative motor neuronopathies in which there is a loss of motor neurons leading to progressive muscular weakness and can lead to death. Over the last decade there have been tremendous developments in the management of SMA and MND patients with the development of new and more targeted therapies. As a result there is an urgent need to establish robust measures for ongoing assessment and monitoring of our patients. We are grateful for the support from the Brain Foundation which will help us pursue our research looking into the role of clinical, electrophysiological, molecular and imaging biomarkers in the management of adult patients with motor neuronopathies. Thank you.