 Carbon nanotubes, CNTs, are a promising material for biomedical applications due to their unique mechanical, optical and electrical properties. CNTs have been used in various forms such as free particles, immobilized on substrates, incorporated into nanocomposites, and as scaffolds for tissue engineering. In particular, CNTS hydrogels composites have shown great promise for diagnostic, tissue engineering targeted drug delivery applications. Despite their potential benefits, there remain concerns about the safety of CNTs, which can be addressed through a safe-by-design approach. This article was authored by Juliet Simon, Emanuel Flahout, and Nereo-Golzio.