 First of all acute coronary syndrome is caused by coronary artery disease or CAD which is also known as arthrosclerosis. So I have drawn out here an artery and then we have that black plaque buildup here so that plaque builds up mostly because of poor lifestyle choices and the most common cause is cholesterol. And then what happens is plaque kind of builds up here on the inside of the artery and platelets and blood flow goes through but the platelets say wait a minute there's a plaque going on maybe there's something I need to repair and so then they can aggregate and eventually if they clamp all together here then we have a complete occlusion of that artery which can lead to a myocardial infarction because there's no perfusion this to the part of that clogged artery.