 Roadtrip guide. For many Americans and millions of visitors from all over the world, the best way to see some of the US's most popular sites and to experience the real country and its people is a road trip. This guide gives a breakdown of the most popular routes with suggestions about what to see along the way. Route 66 needs no introduction, as it has been popular with travelers, filmmakers and musicians for decades. It runs between Chicago and Los Angeles and takes in some of America's most stunning natural landscapes, including the Grand Canyon National Park. There are several other popular routes shown, which mainly run between the east and west coast with suggestions on the best time of year to set off so you can avoid any extremes of weather.