 This study examined the attitudes and perceptions of primary care providers, PCPs, directors, and supervisors towards conducting clinical trials, CTs. The findings revealed strong support for the intrinsic scientific value of CTs, as well as deep concerns regarding protecting patient well-being, perceived loss of control when patients participate in trials, concern about the impact of point-of-care referrals on clinic workflow, the need for standard processes, and the need for CT information that enables referring providers to quickly confirm that the burdens are justified by the benefits at both patient and provider levels. Additionally, PCP suggestions pertinent to implementing a CT referral decision support system were reported. These findings provide valuable insights into how to best implement a CT referral decision support system in primary care settings. This article was authored by Theresa Taft, Charlene Weir, Heidi Kramer, and others.