Set five years after the events of Borderlands, Handsome Jack, the game's main antagonist, has taken over the Hyperion Corporation, declared himself Dictator of Pandora and taken all of the credit for finding the Vault, going so far to claim responsibility for killing the Destroyer. Jack has also blotted out much of the light on the planet by having a giant orbiting H-shaped base set in front of Pandora's stationary moon. The new team in Borderlands 2 is tasked with killing Jack and returning peace to Pandora. Borderlands 2 begins with the protagonists on a train to an unspecified location to begin their search for the vault, only for it to turn out as a trap by Handsome Jack to kill all who search for the Vault. The Vault hunters defend themselves only for the train to crash, with them waking up in an arctic wasteland along with Claptrap. The mysterious Guardian Angel then contacts them and explains that Handsome Jack must be killed, directing players to rescue the four original Vault hunters from Hyperion's clutches to accomplish this.
Borderlands 2 initially has four player characters: Axton (Commando), Maya (Siren), Salvador (Gunzerker), Zer0 (Assassin), DLC characters: Gaige (Mechromancer).
Borderlands 2 NPCs include: Brick, Claptrap, Dr. Zed, Ellie, Lilith, Mad Moxxi, Marcus Kincaid, Mordecai, Patricia, Tannis, Roland, Scooter, Sir Hammerlock, Tiny Tina, Crazy Earl.