 The process of melanogenesis involves multiple enzymatic and chemical reactions to synthesize melanin, which is responsible for human skin, eye, and hair pigmentation. Tyrosinase and TRP1 and TRP2 are key enzymes in this process, with tyrosinase being a rate-limiting step. The development of melanogenesis inhibitors has focused on targeting tyrosinase catalytic activity and functionality through various methods such as laboratory synthetic methods, natural products, virtual screening, and structure-based molecular docking studies. This article was authored by Thanagymilipileia, Manoj Manicum, and Vigneshwaran Nommasavayan.